5 Mar 2021 TNF Receptor Superfamily Member 9 · CD137 · Tumor Necrosis Factor Receptor Superfamily Member 9 · T-Cell Antigen 4-1BB Homolog · 4-1BB

CANCER IMMUNOLOGY RESEARCH | RESEARCH ARTICLE CD137/OX40 Bispeciﬁc Antibody Induces Potent Antitumor Activity that Is Dependent on Target Coengagement A C MiguelGaspar,JohnPravin,LeonorRodrigues,SandraUhlenbroich,KatyL.Everett,FranciscaWollerton,

CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. Agonist monoclonal antibodies (mAb) to the immune costimulatory molecule CD137, also known as 4-1BB, are presently in clinical trials for cancer treatment on the basis of their costimulatory effects on primed T cells and perhaps other cells of the immune system. Here we provide evidence that CD137 is selectively expressed on the surface of tumor endothelial cells.

The functions T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells. AU - Lindstedt, Malin. AU - Johansson Lindbom, Bengt. AU - Borrebaeck, Carl.

Intratumoral administration of pro-inflammatory allogeneic, "off-the-shelf", dendritic cells in combination with anti-PD-1 or anti-CD137 has a

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"Förlängd överlevnad med anti-CD137/4-1BB immunstärkare ger möjlighet till att utöka ilixadencels valmöjligheter i kombinationsterapier och

137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. CD137 (4-1BB, TNFRSF9) is increasingly recognized as a pow-erful inducer of antitumor immune responses. The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor. Several agonistic anti‐CD137 antibodies are currently in clinical trials for tumor immunotherapy. Soluble forms of CD137 (sCD137) are generated by differential splicing and antagonize the activities of membrane‐bound CD137 (mCD137) and of therapeutic CD137 agonists.

About 90 % of inibition was seen using a concentration of 1 … CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4 + and CD 8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. 4-1BB (CD137, TNFRSF9) is a surface glycoprotein discovered by Kwon’s group as an activation antigen on the surface of T cells (Kwon and Weissman, 1989).Indeed, its regulated expression is induced upon CD3-TCR engagement and is further stimulated by CD28 ligation (Melero et al., 1998).Its expression is not confined to the T cell lineage since it is inducible on natural killer cells, B Entry name i: TNR9_HUMAN: Accession i: Q07011 Primary (citable) accession number: Q07011: Entry history i: Integrated into UniProtKB/Swiss-Prot: : February 1, 1995: Last sequence update: : February 1, 1995: Last modified: : April 7, 2021: This is version 184 of the entry and version 1 of the sequence. See complete history.: Entry status i: Reviewed (UniProtKB/Swiss-Prot): Annotation program 2013-12-19 The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells.
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Methods Foxp3+ and CD8+ T cells in GCs were investigated using immunohistochemistry (IHC). CD137 expression in GCs was detected using flow cytometry, IHC and immunofluorescence (IF). Peripheral blood mononuclear cells (PBMCs 2019-11-08 · The tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137 or 4-1BB, is another important immune-modulating molecule known to be expressed on the surface of certain immune cells.

It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
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Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor

Mouse CD137 Matched Antibody Pair Kit (ab216788) 4-1BB (CD137, TNFRSF9) is a surface glycoprotein discovered by Kwon’s group as an activation antigen on the surface of T cells (Kwon and Weissman, 1989).Indeed, its regulated expression is induced upon CD3-TCR engagement and is further stimulated by CD28 ligation (Melero et al., 1998). Purpose: Upregulation of CD137 (4-1BB) on recently activated CD8+ T cells has been used to identify rare viral or tumor antigen-specific T cells from peripheral blood. Here, we evaluated the immunobiology of CD137 in human cancer and the utility of a CD137-positive separation methodology for the identification and enrichment of fresh tumor-reactive tumor-infiltrating lymphocytes (TIL) or tumor Interestingly, CD137 expression on tumor-associated CD8+ T cells was largely restricted to a subset that highly expressed PD-1.

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CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses (1). The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis (2). CD137 helps regulate the activation of many immune cells, including CD4(+) T cells, CD8(+) T cells, dendritic cells, and natural killer cells.

4-1BB is also expressed on Tregs and DCs. CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes. Targeting CD137 or its ligand (CD137L) has been studied, aiming to enhance anticancer immune responses. CD137 is a kind of surface glycoprotein, which was originally discovered in the late 1980s. 6 It has been found that CD137 is expressed in a vari- ety of cells, for example, T cells, B cells, natural killer (NK) cells, dendritic CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells. It is also found on both NK and dendritic cells. CD137.